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Sir Christopher Wren making his first demonstration of a method of introducing drugs into a vein, while Dr Thomas Willis looks on, 1667. Oil painting by Ernest Board, c. 1920. Sir Christopher Wren (1632-1723) was an English architect accorded responsibility for rebuilding 52 churches in the City of London after the Great Fire in 1666, including his masterpiece, St. Paul's Cathedral, completed in 1710. Apart from his work as an architect, Wren was also a notable anatomist, astronomer, geometer, and mathematician-physicist. He was a founder of the Royal Society (president 1680-82). Thomas Willis (1621-1675) was an English doctor who played an important part in the history of anatomy, neurology and psychiatry. He was also a founding member of the Royal Society.